Impact of Sarcoidosis on In-hospital Outcomes Among Patients with Atrial Fibrillation: A Nationwide Readmissions Database Analysis

DOI: 10.19102/icrm.2024.15035

MIN CHOON TAN, MD,^1,2 QI XUAN ANG, MBBS,³ YONG HAO YEO, MBBS,⁴ BOON JIAN SAN, MBBS,⁵ RAMZI IBRAHIM, MD,⁶ SZE JIA NG, MD,⁷ JIAN LIANG TAN, MD,⁸ JASJIT WALIA, MD,⁹ ADDI SULEIMAN, MD,⁹ and JOAQUIM CORREIA, MD⁹

¹Department of Internal Medicine, New York Medical College at Saint Michael’s Medical Center, Newark, NJ, USA

²Department of Cardiovascular Medicine, Mayo Clinic, Phoenix, AZ, USA

³Department of Internal Medicine, Sparrow Health System and Michigan State University, East Lansing, MI, USA

⁴Department of Internal Medicine/Pediatrics, Beaumont Health, Royal Oak, MI, USA

⁵AIMST University, Bedong, Malaysia

⁶Department of Internal Medicine, University of Arizona—Banner University Medical Center, Tucson, AZ, USA

⁷Department of Internal Medicine, Crozer-Chester Medical Center, Upland, PA, USA

⁸Department of Cardiovascular Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA

⁹Department of Cardiovascular Medicine, New York Medical College at Saint Michael’s Medical Center, Newark, NJ, USA

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ABSTRACT. Sarcoidosis is a disease that involves multiple organs, including the cardiovascular system. While cardiac sarcoidosis has been increasingly recognized, the impact of sarcoidosis on atrial fibrillation (AF) is not well established. This study aimed to analyze the impact of sarcoidosis on in-hospital outcomes among patients who were admitted for a primary diagnosis of AF. Using the all-payer, nationally representative Nationwide Readmissions Database, our study included patients aged ≥18 years who were admitted for AF between 2017–2020. We stratified the cohort into two groups depending on the presence of sarcoidosis diagnosis. The in-hospital outcomes were assessed between the two groups via propensity score analysis. A total of 1031 (0.27%) AF patients with sarcoidosis and 387,380 (99.73%) AF patients without sarcoidosis were identified in our analysis. Our propensity score analysis of 1031 (50%) patients with AF and sarcoidosis and 1031 (50%) patients with AF but without sarcoidosis revealed comparable outcomes in early mortality (1.55% vs. 1.55%, P = 1.000), prolonged hospital stay (9.51% vs. 9.70%, P = .874), non-home discharge (7.95% vs. 9.89%, P = .108), and 30-day readmission (13.29% vs. 13.69%, P = .797) between the two groups. The cumulative cost of hospitalization was also similar in both groups ($12,632.25 vs. $12,532.63, P = .839). The in-hospital adverse event rates were comparable in both groups. Sarcoidosis is not a risk factor for poorer in-hospital outcomes following AF admission. These findings provide valuable insights into the effectiveness of the current guideline for AF management in patients with concomitant sarcoidosis and AF.

KEYWORDS. Atrial fibrillation, hospital outcomes, sarcoidosis.

The authors report no conflicts of interest for the published content. No funding information was provided.
Manuscript received July 31, 2023. Final version accepted October 10, 2023.
Address correspondence to: Min Choon Tan, MD, Department of Internal Medicine, New York Medical College at Saint Michael’s Medical Center, 111 Central Avenue, Newark, NJ 07102, USA. Email: mctann@yahoo.com.

Background

Sarcoidosis is a systemic inflammatory disorder that affects multiple organs.¹ The deposition of granulomas in cardiac tissue may predispose an individual to atrial or ventricular arrhythmias, conduction system abnormalities, and heart failure.^2–5 Atrial fibrillation (AF) remains the most common type of supraventricular arrhythmia in patients with sarcoidosis, with a prevalence of 12%–18%.^6,7 However, data on the impact of sarcoidosis on in-hospital outcomes among those with AF are not well established.

Methods

We queried the all-payer, nationally representative Nationwide Readmissions Database to analyze patients aged ≥18 years who were admitted for AF between January and November during each calendar year from 2017–2020. We stratified the cohort into two groups based on the presence or absence of sarcoidosis diagnosis using the International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) diagnosis code D86. The main outcomes examined were: (1) in-hospital adverse events, (2) length of stay, (3) discharge disposition, (4) 30-day readmission rate, (5) early mortality (mortality during index hospitalization and readmission), and (6) cumulative cost of hospitalization. As the Nationwide Readmissions Database provides de-identified patient data and is publicly accessible, institutional review board approval was not required for this study.

Continuous data were summarized as mean with standard deviation values or median with interquartile range (Q1, Q3) values depending on their distribution; differences between groups were tested using Wilcoxon rank-sum tests. Categorical data were summarized as counts and percentages; differences between groups were tested using Pearson’s chi-squared test. All tests were two-sided with P ≤ .05, indicating statistical significance. Statistical analyses were conducted using Stata version 12.1 (Stata Corporation, College Station, TX, USA). To identify the association between sarcoidosis and in-hospital outcomes, weighted propensity score matching was first performed with a caliper of 0.2 with a nearest-neighbor ratio of 1:1 for each hospital outcome. Then, all variables outlined in Table 1, including sarcoidosis, were included in the univariable analysis to study their association with the outcome variables listed in Table 2. Those relevant variables with P < .1 were included in a multivariable model for conditional logistic regression analyses.

Results

We identified a total of 388,411 patients hospitalized with AF in the United States from 2017–2020. Our respective cohort consisted of 1031 (0.27%) AF patients with sarcoidosis and 387,380 (99.73%) AF patients without sarcoidosis. Table 1 depicts the baseline characteristics of our patient cohort. AF patients with sarcoidosis were younger and had greater prevalence rates of chronic kidney disease, chronic pulmonary disease, heart failure, non-ischemic cardiomyopathy, obstructive sleep apnea, peripheral vascular disease, prior implantable cardioverter-defibrillator placement, and pulmonary hypertension. A propensity score analysis was performed, which yielded 1031 (50%) patients with AF and sarcoidosis and 1031 (50%) patients with AF but without sarcoidosis. There was no difference in early mortality (1.55% vs. 1.37%, P = 1.00), prolonged hospital stay ≥7 days (9.51% vs. 9.03%, P = .87), non-home discharge (7.95% vs. 11.18%, P = .11), or 30-day readmission (13.29% vs. 12.86%, P = .80) when compared among patients with and without sarcoidosis who were admitted for AF (Table 2). The cumulative cost of hospitalization was also similar in both groups ($12,632.25 vs. $12,532.63, P = .84). There was no significant difference in rates of in-hospital adverse events between both groups, including acute heart failure (16.68% vs. 17.05%, P = .46), cardiogenic shock (0.48% vs. 0.47%, P = .57), cardiac arrest (0.48% vs. 0.23%, P = 1.00), cerebral infarct (0.48% vs. 0.30%, P = .71), pulmonary edema (1.36% vs. 0.79%, P = .08), acute kidney injury (12.71% vs. 11.63%, P = .84), and venous thromboembolism (0.97% vs. 0.83%, P = .64). Further subgroup analysis revealed that sarcoidosis was not independently associated with greater odds for any in-hospital adverse events among patients with AF (Table 3). Additional subgroup analysis demonstrated decreases of 1.21% and 7.57% in the yearly AF-related admission among the sarcoidosis and non-sarcoidosis cohorts, respectively.

Discussion

This study is the first to provide insights on in-hospital adverse events and 30-day readmission rates among patients with and without sarcoidosis who were admitted for AF in a real-world setting. Despite an increased risk of AF and greater comorbidity burden among patients with sarcoidosis, our study suggests that patients with sarcoidosis and AF did not experience poorer in-hospital outcomes when compared to patients without sarcoidosis.⁶ AF in sarcoidosis was hypothesized to be caused by atrium granuloma leading to scarring and by sarcoid involvement of the lungs and left ventricle, resulting in increased end-diastolic pressure.^6,8 The non-inferior outcomes observed in sarcoidosis provide a reflection of contemporary real-world data on the effectiveness of AF management in sarcoidosis by early diagnosis and treatment of cardiac sarcoidosis as well as early intervention, including rate control, rhythm control, or even catheter ablation, as per guideline in all AF patients regardless of the underlying etiology.^5,9,10 Our study also demonstrates that sarcoidosis is not an independent risk factor of in-hospital adverse events during hospitalization.

Limitations

It is important to acknowledge a few main limitations of this study. First, as with most large administrative database studies, the main limitation includes potential miscoding in primary diagnoses and under-reporting of secondary diagnoses. Next, the out-of-hospital deaths that occurred prior to readmission were not recorded, which limits our early mortality to in-hospital mortality. Furthermore, clinical information, including the duration of AF, cardiac involvement of sarcoidosis, and anti-arrhythmic medications, was not available in the database, limiting our attempts to explore the impact of these clinical variables on hospital outcomes.

Conclusion

Our study suggests that sarcoidosis is not associated with poorer hospital outcomes among patients hospitalized for AF. These findings provide valuable insights into the effectiveness of the current guideline for AF management in patients with concomitant sarcoidosis and AF.

References

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